Catalog Number - 60022-05P

60022-05P Cogent RP PFP™ HPLC Column has been a premium value trusted by HPLC laboratories for many years, delivering consistent performance and enhanced selectivity for challenging separations. This column is fully double end‑capped and bonded via a four‑carbon linker to a benzene ring substituted with five fluorine atoms, using ultra‑high purity silica.

The column enables multiple retention mechanisms—including π‑π interactions, dipole interactions, and hydrogen bonding—making it highly effective for halogenated, aromatic, and polar analytes. It is also suitable as an alternate column for USP methods requiring L43 classification.

With a 5 µm particle size, this column provides lower backpressure compared to smaller particles, allowing higher flow rates and robust, reproducible performance across standard analytical HPLC systems.

50 mm Length – Fast Screening and High Throughput

The 50 mm length is optimized for rapid analysis, making it ideal for high-throughput environments and method development.

• Fast run times for efficient sample throughput

• Reduced solvent consumption

• Ideal for screening and rapid method optimization

✅ Recommended for QA/QC labs and fast analytical workflows

Flow Rate & System Requirements (4.6 mm ID, 5 µm)

⚠️ Fully compatible with standard analytical HPLC systems with lower backpressure

• Typical flow rate range: ~1.0 – 2.0 mL/min

• Lower backpressure than 3 µm columns

• Supports higher flow rates for faster analysis

• Compatible with UV and standard detectors

✅ Best Practice: Filter samples using a 0.2 µm syringe filter prior to injection

Why Choose PFP (F5) Columns for Selective Separations

Enhanced Retention for Halogenated Compounds

• Strong interaction with fluorinated and halogenated analytes

• Improved selectivity vs C18 columns

Multiple Interaction Mechanisms

• π‑π interactions for aromatic compounds

• Dipole and hydrogen bonding interactions

• Greater flexibility for method development

60 Å Pore Structure

• Optimized for small molecule separations

• Efficient interaction for lower molecular weight analytes

Cogent RP PFP™ Column Advantages

Fully End‑Capped Surface

• Minimizes silanol activity

• Improves peak symmetry

Robust Performance (5 µm Particles)

• Lower backpressure vs smaller particles

• Reliable and consistent operation

High Purity Silica

• Reproducible chromatographic results

• Long column lifetime

Typical Applications

• Rapid screening of halogenated compounds

• Aromatic compound separations

• Pharmaceutical QA/QC testing

• Method development and optimization

• USP L43 methods

Important Usage Notes

• Packed and shipped in reversed‑phase solvents

• Designed for standard analytical HPLC systems (4.6 mm ID)

• Lower backpressure compared to smaller particle columns

• Use 0.45 µm filtration prior to injection